The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 1995
Filed:
May. 11, 1992
Applicant:
Inventors:
Jack D Keene, Durham, NC (US);
Peter H King, Birmingham, AL (US);
Assignee:
Duke University, Durham, NC (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K / ;
U.S. Cl.
CPC ...
530300 ; 530350 ;
Abstract
A peptide, Hel-N1 (SEQ ID NO: 2), which can bind to a 3'-untranslated mRNA sequence (which encompasses the 'instability sequence') that is uniquely present in the messenger RNAs that encode oncoproteins and lymphokines, and mediates the specific destruction of the messenger RNAs, is described. Full-length Hel-N1 is capable of suppressing cell growth and causing cellular differentiation. Hel-N1 (SEQ ID NO: 2) possess three RNA recognition motifs. One of these forms an RNA-binding domain which, when transfected alone into cells, causes them to undergo rapid growth.