The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 15, 1995
Filed:
Jul. 23, 1993
Matthias A Hediger, Brookline, MA (US);
Brigham and Women's Hospital, Boston, MA (US);
Abstract
An isolated nucleotide sequence encoding a urea transporter polypeptide or unique fragments of urea transporter polypeptide, is provided. One embodiment is an isolated DNA sequence (SEQ ID NO.:1) encoding a urea transporter polypeptide, that has at least two extended hydrophobic domains, each domain lacking interspersed hydrophilic domains. Also described are recombinant cells and plasmids containing the foregoing isolated DNA, preferably linked to a promoter. Isolated urea transporter polypeptide is provided, having at least two extended hydrophobic domains, each domain lacking interspersed hydrophilic domains (SEQ ID NO.:2). Portions of the foregoing isolated urea transporter polypeptides are also described. Antibodies with selective binding specificity for the polypeptides of the invention also are provided. Methods for producing urea transporter polypeptide as well as methods for testing for modulators of urea transporter polypeptide activity are also described.