The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 1995
Filed:
Mar. 24, 1993
Takao Ohmura, Osaka, JP;
Akinori Sumi, Osaka, JP;
Wataru Ohtani, Osaka, JP;
Naoto Fuluhata, Osaka, JP;
Kazuya Takeshima, Osaka, JP;
Kaeko Kamide, Osaka, JP;
Munehiro Noda, Osaka, JP;
Masahide Kondo, Osaka, JP;
Syoichi Ishikawa, Osaka, JP;
Kazuhiro Oohara, Osaka, JP;
Kazumasa Yokoyama, Osaka, JP;
The Green Cross Corporation, Osaka, JP;
Abstract
Human serum albumin obtained by gene manipulation techniques can be purified by a combination of specified steps in which a culture supernatant obtained from a human serum albumin-producing host is subjected to ultrafiltration, heat treatment, acid treatment and another ultrafiltration, followed by subsequent treatments with a cation exchanger, a hydrophobic chromatography carrier and an anion exchanger, and by salting-out to thereby obtain a pure form of human serum albumin which contains substantially no proteinous and polysaccharide contaminants, which is formulated into a pharmaceutical preparation. This process makes it possible to effeciently purify recombinant human serum albumin and to provide substantially pure human serum albumin which does not contain producer host-related substances and other contaminants and is sufficiently free from coloration.