The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 1995
Filed:
Nov. 16, 1992
Thomas S Edgington, La Jolla, CA (US);
Robert W Colman, Moylan, PA (US);
Janos Kappelmayer, Debrecen, HU;
L Henry Edmunds, Jr, Bryn Mawr, PA (US);
Alvise Bernabei, Philadelphia, PA (US);
The Scripps Research Institute, La Jolla, CA (US);
Trustees of the University of Pennsylvania, Phialdelphia, PA (US);
Temple University - Of the Commonwealth Systems of Higher Education, Phialdelphia, PA (US);
Abstract
This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods.