The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 1995
Filed:
Mar. 16, 1993
Takeda Chemical Industries, Ltd., Osaka, JP;
Abstract
Parathyroid hormone (PTH) derivatives represented by the general formula: ##STR1## or a salt thereof, wherein R.sub.1 represents Ser or a D-.alpha.-amino acid residue of 4 or less carbon atoms; R.sub.2 represents a tetrapeptide chain which contains at least one water-soluble .alpha.-amino acid residue; R.sub.3 represents a tripeptide chain which contains at least one water-soluble .alpha.-amino acid residue; and R.sub.4 represents an aromatic amino acid residue or an amide thereof, except that R.sub.1 is Ser when R.sub.2 is His-Leu-Asn-Ser, R.sub.3 is E-F-G wherein E is Arg or His, F is Lys or His, G is Lys, Leu or Gln, are disclosed. The parathyroid hormone derivatives of the present invention are stable and have high biological activity, therefore they are useful as drugs for bone diseases and the like.