The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 1995
Filed:
Jan. 31, 1992
Shoji Tanaka, Hyogo, JP;
Yoshiharu Minamitake, Kanagawa, JP;
Yasuo Kitajima, Osaka, JP;
Mayumi Furuya, Osaka, JP;
Hisayuki Matsuo, Higashinada-ku, Kobe-shi, Hyogo-ken, JP;
Suntory Limited, both of, JP;
Other;
Abstract
Novel peptides represented by the general formula: ##STR1## and physiologically acceptable acid addition salts thereof; where (A) represents H-, H-Gly, H-Lys-Gly, H-Ser-Lys-Gly, H-Leu-Ser-Lys-Gly, H-Gly-Leu-Ser-Lys-Gly, H-ser, H-Ser-Ser, H-Arg-Ser-Ser, H-Arg-Arg-Ser-Ser, H-Leu-Arg-Arg-Ser-Ser, H-Ser-Leu-Arg-Arg-Ser-Ser; (B) represents H-Cys or Pmp; (C) represents Phe-, pCl-Phe, pF-Phe, pNO.sub.2 -Phe or Cha; (D) represents Ile, Val, Aib, tLeu, Gly or Leu; (E) represents Lys or Arg; (F) represents Ile, Leu or Met; (G) represents Ser or Ala; (H) represents Met or Gln; (I) represents --OH, -Asn-OH, -Asn-Ser-OH, -Asn-Ser-Phe-OH, -Asn-Ser-Phe-Arg-OH or -Asn-Ser-Phe-Arg-Tyr-OH; and the symbol ' . . . ' represents a disulfide bond; provided that 1) .alpha.-hANP, 2) .alpha.-hANP (7-28) and 3) CNP-22 are excluded from the scope of that general formula. Also disclosed are agents for suppressing the growth of vascular smooth muscle cells that contains those peptides as effective ingredients.