The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 1995
Filed:
Dec. 22, 1993
Ryoichi Ando, Kanagawa, JP;
Naoko Ando, Kanagawa, JP;
Hirokazu Masuda, Kanagawa, JP;
Toshiro Sasaki, Tokyo, JP;
Yasuhiro Morinaka, Ibaraki, JP;
Chizuko Takahashi, Kanagawa, JP;
Yoshikuni Tamao, Tokyo, JP;
Akihiro Tobe, Kanagawa, JP;
Mitsubishi Kasei Corporation, Tokyo, JP;
Abstract
Aminoketone derivatives according to the present invention strongly inhibit thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L or the like and have excellent properties concerning absorbance on oral administration, tissue distribution and cell membrane permeability. The aminoketone derivatives cart thus be used as therapeutic agents for treating muscular dystrophy, cataract, cardiac infarction, stroke, Alzheimer's disease, amyotrophy, osteoporosis and hypercalcemia and so on. It may also be used as therapeutic agents for preventing metastasis of cancer. In addition, the present derivatives are also applicable as intermediates for the preparation of ketone derivatives, which have inhibitory activity against thiol protease.