The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 1995
Filed:
Apr. 09, 1993
Hiroyuki Kato, Ibaraki, JP;
Shinji Yoshitake, Ibaraki, JP;
Suguru Suzuki, Ibaraki, JP;
Noboru Suzuki, Ibaraki, JP;
Toshio Seto, Ibaraki, JP;
Naoko Nagaoka, Ibaraki, JP;
Yoshiharu Mizui, Ibaraki, JP;
Eisai Co., Ltd., Tokyo, JP;
Abstract
A novel human antithrombin III (AT III) mutant having a high antithrombin activity in the absence of heparin and effective in the treatment of thrombotic disorders as an anticoagulant, which is obtained by mutating amino acids at the reactive site and the heparin binding site of human AT III into another amino acids with the use of the recombinant DNA technology with the use of a DNA coding for AT III as a template. The invention also relates to a method for mass producing the above-described mutant by incubating a host transformed by an expression vector having the cDNA of the mutant inserted therein.