The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 1995
Filed:
May. 10, 1993
Applicant:
Inventors:
Janusz J Kulagowski, Bishops Stortford, GB;
Paul D Leeson, Cambridge, GB;
Ian M Mawer, Bishops Stortford, GB;
Assignee:
Merck Sharp & Dohme Ltd., Hoddesdon, GB;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
514425 ; 5142355 ; 514343 ; 514414 ; 548544 ; 548511 ; 548469 ; 548454 ; 546281 ; 544 82 ; 544124 ; 544131 ; 544141 ;
Abstract
A class of 4-hydroxy-2(1H)-pyrrolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist.