The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 1995
Filed:
May. 11, 1993
Applicant:
Inventors:
Giorgio Carta, Charlottesville, VA (US);
Michael J Conder, Harrisonburg, VA (US);
John L Gainer, Charlottesville, VA (US);
Robert W Stieber, Harrisonburg, VA (US);
Victor A Vinci, Charlottesville, VA (US);
Timothy W Weber, Grampian, PA (US);
Assignees:
Merck & Co., Inc., Rahway, NJ (US);
The University of Virginia Alumni Patents Foundation, Charlottesville, VA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P / ;
U.S. Cl.
CPC ...
435125 ; 425280 ; 425921 ;
Abstract
An immobilized lipase is employed in an organic solvent to esterify diol lactone derivatives of HMG-CoA reductase inhibitors to form HMG-CoA reductase inhibitors of formula (I). ##STR1## This process allows for the efficient, one-step production of HMG-CoA reductase inhibitors of structural formula (I).