The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 23, 1995
Filed:
Oct. 04, 1993
Rebecca A Wallace, Manchester, MO (US);
Mallinckrodt Medical, Inc., St. Louis, MO (US);
Abstract
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein V is CR.sub.1 or N; W is CR.sub.2 or N; R.sub.1 and R.sub.2 may be the same or different and are hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, optionally R.sub.1 and R.sub.2 may be substituted by one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.3, CONR.sub.4 R.sub.5, or --NR.sub.4 R.sub.5 ; X and Y may be the same or different and the O, NR.sub.6, S, or CR.sub.7 R.sub.8 ; R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 may be the same or different and are hydrogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, or C.sub.1 -C.sub.8 alkoxyalkyl; R.sub.4 and R.sub.5 may form a 5 or 6 membered carbocyclic ring optionally containing singularly or in combination nitrogen, oxygen or sulfur; a, b, c, d and e may be same or different and are zero to about 10; and Z is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H, or --CONHOH. Methods for imaging using compositions of the invention as diagnostic imaging agents are also provided.