The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 1995
Filed:
Aug. 20, 1992
Applicant:
Inventors:
Jindrich Kopecek, Salt Lake City, UT (US);
Sung W Kim, Salt Lake City, UT (US);
Helle Brondsted, Salt Lake City, UT (US);
Pavla Kopeckova, Salt Lake City, UT (US);
Assignee:
University of Utah Research Foundation, Salt Lake City, UT (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61F / ;
U.S. Cl.
CPC ...
424436 ; 424 7835 ; 424438 ; 424468 ; 424487 ; 526306 ; 526307 ;
Abstract
Colonic-targeted oral drug dosage forms composed of a drug confined within a crosslinked hydrogel that exhibits pH-dependent swelling and is composed of an ionizable comonomer such as acrylic acid, a nonionizable comonomer such as an acrylamide, and a crosslinking agent that contains an aromatic azobond. Selective drug release in the colon occurs by a combination of pH-dependent swelling of the hydrogel and degradation of the hydrogel by enzymatic cleavage of the azobonds by azoreductases.