The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 1995
Filed:
Mar. 15, 1993
Applicant:
Inventors:
Koichi Niimura, Saitama, JP;
Takako Kawabe, Saitama, JP;
Takao Ando, Tokyo, JP;
Kenichi Saito, Tokyo, JP;
Assignee:
Kureha Chemical Industry Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07C / ;
U.S. Cl.
CPC ...
514269 ; 514274 ; 514533 ; 514534 ; 514538 ; 514539 ; 514542 ; 514563 ; 544311 ; 544312 ; 544313 ; 560 21 ; 560 22 ; 560 29 ; 560 32 ; 562445 ; 562448 ;
Abstract
A phenylalanine-glycine compound of formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described. The novel conjugate of the phenylalanine-glycine compound and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered alone or as a mixture with phenylalanine.