The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 1995
Filed:
Feb. 25, 1993
Jeanne A Itak, Hamilton, NJ (US);
James R Fleeker, Fargo, ND (US);
David P Herzog, Warrington, PA (US);
Ohmicron Corporation, Newtown, PA (US);
Abstract
There is provided a standard for use in testing for captan in immunoassays. This standard has the structure THPD--(CH.sub.2).sub.x --(R.sup.3).sub.y --R.sup.1 wherein THPD is cis-1,2,3,6-tetrahydrophthalimido, x is an integer from 1 to 10, R.sup.1 selected from the group consisting of --COOH, --NH.sub.2, --NO.sub.2, --SH and --OH, R.sup.3 is an aryl moiety and y is 0 or 1. Compounds of this general structure are known, they mimic the immunological reaction of captan and related compounds which are not stable in water and thus cannot be satisfactorily used as standards in testing for the presence and level of presence of captan and related compounds. There is also provided a method of carrying out such testing, utilizing such standards in which the standard (I) is coupled to a protein that is large enough to elicit an immune response in warm blooded animals, to yield compound (II). THPD--(CH.sub.2).sub.x --(R.sup.3).sub.y --R.sup.2 --[--C*--]--[LP] (II), wherein C** is a coupling agent capable of coupling a member of the group R.sup.1 to a protein, R.sup.2 is the residue remaining when R.sup.1 is coupled with coupling agent C**, C* is the residue remaining from coupling agent C** after coupling a member of the group R.sup.1 to a protein and LP is a protein of sufficient size to generate an antibody response in a warm blooded animal.