The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 1995
Filed:
Jan. 13, 1994
Gregory R Mundy, San Antonio, TX (US);
Gloria E Gutierrez, San Antonio, TX (US);
Ian R Garrett, San Antonio, TX (US);
Massimo Sabatini, Neuilly-sur-Seine, FR;
Elzbieta Izbicka, San Antonio, TX (US);
Wilson Burgess, Gaithersburg, VA (US);
Gregg R Crumley, Philadelphia, PA (US);
Clarence C Morse, King of Prussia, PA (US);
Timothy R Arnett, San Antonio, TX (US);
Rhone-Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA (US);
OsteoSA Inc., Collegeville, PA (US);
Abstract
The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising polypeptides containing the amino acid sequence M-A-G-L-G-D-E-F-G-D, [SEQ ID NO: 1], (X) F E T L F G A/V E D V I/D A L Q F V C G D, [SEQ ID NO: 2], or A-Y-I-P-I-E-T-L-E-G-I/G-E-L-V-D/Q-T-G/L-Q-F, [SEQ ID NO: 3], or biologically active fragments or sequence analogues thereof. Among the biological properties of the proteinaceous materials of the present invention is the capability to promote the growth and/or differentiation of osteoblastic cells.