The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 1995
Filed:
Nov. 23, 1993
Applicant:
Inventors:
Jackson B Hester, Jr, Galesbury, MI (US);
Salvatore C Perricone, Delton, MI (US);
J Kenneth Gibson, Kalamazoo, MI (US);
Assignee:
The Upjohn Company, Kalamazoo, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
564 99 ; 560251 ;
Abstract
Methanesulfonamides are structurally depicted by Formula I' ##STR1## or its pharmacologically acceptable salts where R.sub.3 is a C.sub.1-7 alkyl substituted with C.sub.3-7 cycloalkyl, or a C.sub.1-10 alkyl substituted with one to eight fluorine atoms, one to three hydroxy, one to three C.sub.1-5 acyloxy or one to three C.sub.1-4 alkoxy substituents. These compounds are useful as Class III antiarrhythmic agents and are stable against rapid metabolism. Methods for treating cardiac arrhythmias with the compounds of Formula I' as well as compositions thereof are also described.