The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 1995
Filed:
Sep. 07, 1993
Applicant:
Inventors:
Yoshikazu Iwasawa, Tsukuba, JP;
Hiromi Hattori, Tsukuba, JP;
Yasufumi Nagata, Tsukuba, JP;
Akiko Shimizu, Tsukuba, JP;
Yoshio Sawasaki, Tsukuba, JP;
Assignee:
Banyu Pharmaceutical Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
514618 ; 514274 ; 514312 ; 514351 ; 514398 ; 514468 ; 514617 ; 514824 ; 544301 ; 546153 ; 546300 ; 5483245 ; 549460 ; 564162 ; 564161 ;
Abstract
There are provided substituted acetamide derivatives represented by general formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, n and Z are defined in the specification. The substituted acetamide derivatives strongly inhibit acylcoenzyme A cholesterol acyltransferase (ACTA) and are expected to be effective for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.