The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 1995
Filed:
Apr. 30, 1993
Anil K Saksena, Upper Montclair, NJ (US);
Viyyoor M Girijavallabhan, Parsippany, NJ (US);
Russell E Pike, Stanhope, NJ (US);
Haiyan Wang, Bayton, NJ (US);
Raymond G Lovey, West Caldwell, NJ (US);
Yi-Tsung Liu, Morris Township, Morris County, NJ (US);
Ashit K Ganguly, Upper Montclair, NJ (US);
William B Morgan, Chatham Township, Morris County, NJ (US);
Aleksey Zaks, Hoboken, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
Disclosed is a process for preparing chiral compounds of the formula (I) ##STR1## wherein: X.sup.1 and X.sup.2 are independently F or Cl; and E is --SO.sub.2 R.sup.2, wherein R.sup.2 is C.sub.1 -C.sub.6 alkyl, --C.sub.6 H.sub.4 CH.sub.3 or --CF.sub.3 ; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula ##STR2## wherein: X.sup.1 and X.sup.2 are independently F or Cl; B represents --C(O)Q* or --CH.sub.2 OR'; Q* represents a chiral auxiliary group; R' represents a hydroxy protecting group selected from --CH.sub.2 C.sub.6 H.sub.5, or --C(O)R.sup.1, wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.