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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5401742 B1

PDFFull Text
Date of Patent:
Mar. 28, 1995

Filed:

Mar. 18, 1994

Polymeric conjugate of methotrexate compound and pyran copolymer and

Applicant:
Inventors:

Takashi Hirano, Ibaraki, JP;

Takeshi Todoroki, Ibaraki, JP;

Shinichi Ohashi, Ibaraki, JP;

Tomokuni Kokubu, Ibaraki, JP;

Hideaki Tanaka, Ibaraki, JP;

Assignee:

Japan, as represented by Director General of Agency of Industrial, , US;

Attorney:

Wenderoth, Lind & Ponack

Primary Examiner:

Joseph E Evans

Int. Cl.
CPC ...
A61K / ; C08L / ; C08F / ;
U.S. Cl.
CPC ...
514249 ; 5253272 ; 525375 ;
Abstract

Methotrexate, which is a known anticancer agent, can be converted into a polymeric conjugate with a pyran copolymer, which in itself has a certain anticancer effect, by a method in which an alkylene diamine is reacted with the carboxyl group of the methotrexate molecule to give an amidation product having a free amino group in a molecule, which is then reacted with the carboxyl group of the pyran copolymer, of which at least 10% of the repeating units have been modified with the methotrexate residue. The polymeric conjugate has sustained releasability of the methotrexate compound in blood serum so that an excellent therapeutic effect can be obtained by the administration thereof against cancers with little problems due to the side effects caused by an unduly high concentration of the drug in blood unavoidable when methotrexate as such is administrated.

Find Patent Forward Citations

Hirano, Takashi. (1995). Polymeric conjugate of methotrexate compound and pyran copolymer and (U.S. Patent No. 5401742). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5401742

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