The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 17, 1995
Filed:
May. 25, 1993
Tibor Szanya, Veszprem, HU;
Laszlo Hanak, Boldogkoujfalu, HU;
Gyongyi Strbka, Veszprem, HU;
Edit Nagy, Debrecen, HU;
Istvan Melczer, Debrecen, HU;
Gyorgy Deak, Debrecen, HU;
Berta Mako, Debrecen, HU;
Anita Karczub, Hajdunanas, HU;
Janos Balint, Debrecen, HU;
Ferenc Radnai, Debrecen, HU;
Erno Karacxony, Debrecen, HU;
Csaba Hajdufi, Debrecen, HU;
Vilmos Keri, Debrecen, HU;
Gyula Marton, Veszprem, HU;
Judit Dencs, Veszprem, HU;
Janos Kelemen, Veszprem, HU;
Biogal Gyogyszerarugyar RT, Debrecen, HU;
Abstract
A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.