The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 1995
Filed:
Aug. 19, 1993
Bernd Boedecker, Hannover, DE;
Friederike Henninges, Brunswick, DE;
Klaus-Juergen Koelln, Neustadt a. Rbge, DE;
Guenther Kuhnow, Neustadt a. Rbge, DE;
Guenter-Josef Peschke, Hanover, DE;
Manfred Rehburg, Wagenfeld, DE;
Alwin Sobe, Sarstedt, DE;
Berthold Stemmle, Burgdorf, DE;
Kali-Chemie Pharma GmbH, Hanover, DE;
Abstract
Pancreatin-containing micropellet cores which can be coated with a gastric juice-resistant film are prepared by extruding a mixture containing pancreatin, polyethylene glycol 4000 and a lower alcohol such as propan-2-ol to produce extrudates which break by themselves into fragments, rounding the fragments with the addition of highly liquid paraffin and drying. Propan-2-ol may be present with the paraffin during rounding. The micropellet cores contain 65-85% pancreatin, and have a bulk density of 0.6 g/ml to 0.85 g/ml, a spherical to ellipsoidal shape with a minor axis in the range of 0.7-1.4 mm and a particle size distribution in which at least 80% of the micropellet cores have a minor axis to major axis ratio in the range from 1:1 to 1:2.