The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 1994

Filed:

May. 24, 1993
Applicant:
Inventors:

Noel K Maclaren, Archer, FL (US);

Yao H Song, Gainesville, FL (US);

Assignee:

University of Florida, Gainesville, FL (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
435-74 ; 435 18 ; 436506 ; 436811 ;
Abstract

An epitope of 21-hydroxylase has been identified which specifically reacts with autoantibodies to 21-hydroxylase. This epitope immunoreacts with anti-adrenocortical autoantibodies characteristically present in patients having autoimmune Addison's disease. The peptide can be used in a specific, sensitive immunoassay for the detection of these autoantibodies in the diagnosis of Addison's disease. The immunoassay permits the diagnosis of autoimmune Addison's disease and has considerable value in the screening of persons at risk. Persons in the early phases or at clinical onset of any kind of adrenocortical disease can also be screened to exclude Addison's disease as a cause.


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