The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 1994
Filed:
Mar. 03, 1994
David M Stern, Great Neck, NY (US);
Mehmet C Oz, Fort Lee, NJ (US);
Roman Nowygrod, Teaneck, NJ (US);
Shin Koga, New York, NY (US);
David J Pinsky, Riverdale, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
The present invention provides an aqueous solution for organ preservation or maintenance, including: a vasodilator in an amount sufficient to maintain vascular homeostasis; D-glucose in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; magnesium ions in an amount sufficient to support intracellular function and maintenance of cellular bioenergetics; macromolecules of molecular weight greater than 20,000 daltons in an amount sufficient to maintain endothelial integrity and cellular viability; potassium ions in a concentration greater than about 110 mM; and a buffer in an amount sufficient to maintain the average pH of the organ preservation or maintenance solution during the period of organ preservation at about the physiologic pH value. The invention also provides a method of preserving or maintaining an organ, including contacting the organ with the solution.