The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 1994
Filed:
Mar. 19, 1993
Gregory D Berger, Belle Mead, NJ (US);
James D Bergstrom, Neshanic, NJ (US);
Tesfaye Biftu, Westfield, NJ (US);
Robert L Bugianesi, Colonia, NJ (US);
Robert M Burk, Laguna Beach, CA (US);
Narindar N Girotra, Old Bridge, NJ (US);
C H Kuo, South Plainfield, NJ (US);
William H Parsons, Edison, NJ (US);
Mitree M Ponpipom, Branchburg, NJ (US);
Lori L Whiting, West Carrollton, OH (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.