The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 1994
Filed:
Dec. 06, 1990
Robert D Sindelar, Oxford, MS (US);
Barton J Bradbury, West Chester, OH (US);
Teodoro S Kaufman, Rosario, AR;
Stephen H Ip, Sudbury, MA (US);
Henry C Marsh, Jr, Reading, MA (US);
Chew Lee, Oxford, MS (US);
T Cell Sciences, Inc., Cambridge, MA (US);
The University of Mississippi, University, MS (US);
Abstract
The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain intermediates. The compounds of the present invention, and the phamaceutically acceptable salts thereof, interrupt the proteolytic processing of C5 to bioactive components, exhibit immunosuppressive activites, and have therapeutic utility in the amelioration of disease and disorders mediated by complement and/or immune activity.