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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5364948 B1

PDFFull Text
Date of Patent:
Nov. 15, 1994

Filed:

Feb. 09, 1993

Biologically active compounds isolated from aerobic fermentation of

Applicant:
Inventors:

Guy H Harris, Cranford, NJ (US);

Deborah Zink, Manalapan, NJ (US);

E Tracy Jones, Solana Beach, CA (US);

Yu L Kong, Edison, NJ (US);

Assignee:

Merck & Co., Inc., Rahway, NJ (US);

Attorneys:

Dolan; Catherine A.

Winokur; Melvin

Matukaitis; Paul D.

Primary Examiner:

Jose G Dees

Assistant Examiner:

Deborah D Carr

Int. Cl.
CPC ...
C07C / ;
U.S. Cl.
CPC ...
554 36 ; 554 35 ; 554 61 ; 554 63 ; 554213 ; 554218 ; 554227 ; 554228 ; 554229 ; 548469 ; 548534 ;
Abstract

This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compounds are also potent antifungal agents. Additionally, they inhibit farnesyl protein transferase and farnesylation of the oncogene protein Ras and are thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).

Find Patent Forward Citations

Harris, Guy. (1994). Biologically active compounds isolated from aerobic fermentation of (U.S. Patent No. 5364948). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5364948

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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