The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 1994
Filed:
Dec. 09, 1992
Applicant:
Inventors:
James F Hainfeld, Shoreham, NY (US);
Frederic R Furuya, Williston Park, NY (US);
Assignee:
Associated Universities, Inc., Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; A61K / ;
U.S. Cl.
CPC ...
5303915 ; 5303911 ; 5303913 ; 5303917 ; 5303919 ; 424-9 ; 424-129 ; 424-153 ; 436547 ;
Abstract
Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.