The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 1994
Filed:
Jul. 02, 1992
Applicant:
Inventors:
Susan M Skelly, Dunellen, NJ (US);
Charles T Tackney, Brooklyn, NY (US);
John N Snouwaert, Carrboro, NC (US);
Dana M Fowlkes, Chapel Hill, NC (US);
Assignees:
Imclone Systems Inc., New York, NY (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ;
U.S. Cl.
CPC ...
530351 ; 930141 ; 424 852 ; 424 856 ;
Abstract
Muteins of IL-6 and truncated IL-6 are prepared by recombinant DNA techniques. In the muteins, the cysteine residues that occur at positions, or at positions corresponding to positions, 45 and 51 of mature, native IL-6 have been replaced by other amino acids. The cysteine residues that occur at positions, or at positions corresponding to positions, 74 and 84 are retained. The molecule has biological activity that is at least comparable to that of native IL-6.