The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 1994
Filed:
Jan. 22, 1992
Applicant:
Inventor:
Stephen K Rhind, Wooburn, GB;
Assignee:
Celltech Limited, Slough, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07K / ;
U.S. Cl.
CPC ...
424-149 ; 424-153 ; 424-9 ; 424 943 ; 4241781 ; 4241791 ; 5303911 ; 5303913 ; 5303915 ; 5303917 ; 5303919 ; 436544 ; 436545 ; 436546 ; 435188 ;
Abstract
Cross-linked labelled antibody conjugates are described which have at least one non-disulphide interchain bridge. The bridge may be the residue of a homo- or heterofunctional cross-linking reagent, and is located away from the antigen binding domains of the antibody. The antibody conjugates have an enhanced binding capacity and in vivo have good blood clearance and, in the presence of a tumour high tumour: blood and tumour: bone ratios. The conjugates are of use in the diagnosis and therapy of e.g. tumours and may be prepared by reaction of a cross-linking reagent with an antibody.