The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 1994
Filed:
Dec. 02, 1992
Joseph S Yudelson, Rochester, NY (US);
Sterling Winthrop Inc., New York, NY (US);
Abstract
The present invention is directed to particles comprised of a magnetically responsive material and a dispersant, said particles having a particle size range of about 2 to about 10 nm. The present invention is also directed to a method for the preparation of such particles comprising admixing a magnetically responsive material with a dispersant to form an admixture, and contacting said first admixture with a base for a time period and under conditions appropriate to form a magnetically responsive material-dispersant particle. In a preferred embodiment, the magnetically responsive material is magnetite, the dispersant is dextran, and the base is ammonium hydroxide. In a further preferred embodiment, the admixture is suspended in a gel phase. The present invention is further directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of these particles suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.