The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 1994
Filed:
Mar. 13, 1992
Robert W Guthrie, Saddle Brook, NJ (US);
John G Mullin, Jr, Hawthorne, NJ (US);
David F Kachensky, Milford, PA (US);
Richard W Kierstead, North Caldwell, NJ (US);
Jefferson W Tilley, North Caldwell, NJ (US);
Guy P Heathers, Morristown, NJ (US);
Alan J Higgins, Upper Montclair, NJ (US);
Ronald A LeMahieu, North Caldwell, NJ (US);
Hoffman-La Roche Inc., Nutley, NJ (US);
Abstract
The invention relates to compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric isomer or mixtures thereof, and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction.