The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 1994
Filed:
Sep. 03, 1992
Cary J Morrow, Albuquerque, NM (US);
Joe S Wallace, Albuquerque, NM (US);
University of New Mexico, Albuquerque, NM (US);
Abstract
Methods of separating stereoisomers of a racemic mixtures of a compound employ porcine pancreatic lipase which selectively transesterfies one enantiomer of an ester function which is proximate to a chiral isomeric site are presented. The compound is a reactive ester of the formula: ##STR1## The method comprises obtaining a racemic mixture of the reactive ester, reacting the reactive ester with a poly(ethylene glycol) of average molecular weight of about 100 to about 10,000 Daltons and the enzyme. The reactive ester, the poly(ethylene glycol) and the enzyme are reacted in a medium in proportions other conditions effective to form a chiral site proximate poly(ethylene glycol) ester. The chiral site approximate poly(ethylene glycol) ester is then separated from the reaction medium, the reactive ester, the poly(ethylene glycol) and the enzyme.