The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 1994
Filed:
Sep. 14, 1992
Applicant:
Inventors:
Takayuki Hirayama, Yokohama, JP;
Takashi Kiyota, Yokohama, JP;
Assignee:
Nippon Oil Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C07D / ;
U.S. Cl.
CPC ...
20415821 ; 536 2641 ; 536 2642 ; 536 2643 ; 20415764 ; 20415767 ;
Abstract
A process for the production of hydroxocobalamin that eliminates cyanocobalamin as an intermediate. Co-enzyme-type vitamin B.sub.12 is first absorbed to a divinylbenzene/styrene resin which is washed with warm water and then eluted with a solution containing at least 25% of a lower alcohol. The eluate is then irradiated with a light that causes the conversion of coenzyme-type vitamin B.sub.12 to hydroxocobalamin. Finally, the solution of hydroxocobalamin is treated with alumina or silica which binds the impurities leaving behind the highly purified hydroxocobalamin in the flow-through.