The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 09, 1994

Filed:

Mar. 25, 1993
Applicant:
Inventors:

Klaus Kirschke, Eiche, DE;

Gerhard Lutze, Berlin, DE;

Ernst Schmitz, Berlin, DE;

Erich Wolff, Solingen, DE;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
548371 ;
Abstract

Pyrazolo[5,1-c][1,2,4]triazoles of the general formula I ##STR1## in which R.sup.1 and R.sup.2 represent alkyl, cycloalkyl, aralkyl, aryl, alkoxy or heterocyclic radicals, R.sup.3 is hydrogen, halogen or an alkyl, cycloalkyl, aralkyl, aryl or heterocyclic radical bonded via a hetero atom, wherein R.sup.2 and R.sup.3 may be closed to form a ring, and R.sup.4 is hydrogen or an acyl radical, are prepared from 3(5)-amino-pyrazoles of the general formula II ##STR2## in which R.sup.2 and R.sup.3 have the abovementioned meaning, by reaction with a hydroximoyl halide of the general formula III ##STR3## in which R.sup.1 has the abovementioned meaning and X represents chlorine or bromine, in the presence of a tertiary base to give a 5-amino-1-hydroximoyl-pyrazole, subsequent reaction with an aliphatic or aromatic sulphonyl chloride in the presence of a tertiary base to give an O-sulphonated 5-amino-1-hydroximoyl-pyrazole, acylation to give an O-sulphonated 5-acylamino-1-hydroximoyl-pyrazole or 5-bisacylamino-1-hydroximoyl-pyrazole and then treatment with bases. The optionally O-sulphonated 5-amino-1-hydroximoyl-pyrazoles or O-sulphonated 5-acylamino- and 5-bisacylamino-1-hydroximoyl-pyrazoles are new valuable intermediates for the synthesis of pyrazolo[5,1-c][1,2,4]-triazoles.


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