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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5324652 B1

PDFFull Text
Date of Patent:
Jun. 28, 1994

Filed:

Nov. 06, 1992

Preparation of pepsin substantially devoid of proteolytic activity using

Applicant:
Inventors:

Antonio G Gomez-Pamo, Madrid, ES;

Aurora Brieva Delgado, Madrid, ES;

Juan P Pivel Ranieri, Madrid, ES;

Assignee:

Laboratorios Andromaco SA, Madrid, ES;

Attorney:

Rogers, Howell & Haferkamp

Primary Examiner:

David M Naff

Assistant Examiner:

Michael V Meller

Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; A61K / ;
U.S. Cl.
CPC ...
435219 ; 424 9466 ; 435212 ; 435226 ;
Abstract

A method for producing a composition having an inhibiting effect on production of tumor necrosis factor (TNF), and a method for inhibiting the production of TNF in vivo by administering the composition is provided. The composition comprises a solution of pepsin which has been rendered substantially proteolytically inactive by a series of sequential dialysis against running water, deionized water, and distilled water, respectively, for periods of time sufficient to substantially eliminate the proteolytic activity of the pepsin solution. The resulting composition is combined with a pharmaceutically acceptable carrier and administered in vivo to partially inhibit the production of TNF induced by a bacterial endotoxin.

Find Patent Forward Citations

Gomez-Pamo, Antonio. (1994). Preparation of pepsin substantially devoid of proteolytic activity using (U.S. Patent No. 5324652). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5324652

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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