The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 1994

Filed:

Mar. 04, 1993
Applicant:
Inventors:

Mitsuo Nagano, Tokyo, JP;

Junichi Sakai, Tokyo, JP;

Nobuyoshi Iwata, Tokyo, JP;

Kazuo Kobayashi, Tokyo, JP;

Masao Kozuka, Tokyo, JP;

Kenji Yoshimi, Tokyo, JP;

Katsunori Kato, Tokyo, JP;

Yoshiko Kubo, Tokyo, JP;

Toshiyuki Tonohiro, Tokyo, JP;

Takao Hara, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514379 ; 5142338 ; 5142368 ; 514380 ; 544137 ; 544367 ; 544368 ; 548241 ; 548243 ; 546198 ; 546209 ; 546270 ; 546275 ;
Abstract

Compounds of formula (I): ##STR1## [in which: either (a) the dotted line ( ) is a single bond; A=is oxygen; and B is a group of formula (II): ##STR2## (in which m is 0 and n is 0 or 1) or (b) the dotted line ( ) is a double bond; A=is said group of formula (II) in which m is 1 and n is 0 or 1; and B is absent; and R.sup.1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R.sup.2 is hydrogen, halogen, alkyl, optionally substituted phenyl or heterocyclic; or R.sup.1 and R.sup.2, together with the carbon atoms to which they are attached, are a hydrocarbon ring fused to the isoxazole ring; R.sup.3 and R.sup.4 are each hydrogen, alkyl, optionally substituted benzyl or optionally substituted phenyl; or R.sup.3, R.sup.4 and the nitrogen atom to which they are attached together represent an alicyclic amino group]; and salts thereof may be used for the treatment of cerebral circulatory problems and for use as centrally acting muscle relaxants.


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