The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 1994
Filed:
Jul. 10, 1992
Applicant:
Inventors:
Arthur A Patchett, Westfield, NJ (US);
Raymond F White, Englishtown, NJ (US);
Robert T Goegelman, Linden, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P / ;
U.S. Cl.
CPC ...
435 711 ; 435171 ; 530317 ; 530321 ; 514 11 ;
Abstract
A cyclosporin derivative with incorporated '8-(3-fluoro-D-alanine)' or '8-(2-deutero-3-fluoro-D-alanine)' has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.