The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 03, 1994
Filed:
Jul. 09, 1992
Konica Corporation, Tokyo, JP;
Abstract
A substantially purified cancer-related galactosyltransferase and a monoclonal antibody which may be used as a diagnostic reagent of cancer are disclosed. The galactosyltransferase of the present invention has a molecular weight of about 50,000 determined by SDS-polyacrylamide gel electrophoresis under reducing conditions and has a reactivity with MAb4880 under native conditions. A part of the galactosyltransferase self-associates and its reactivity with MAb4880 and the degree of self-association are promoted when it is reduced so that a part of which is detected in a fraction of a molecular weight of not less than 200,000 in gel permeation chromatography. The galactosyltransferase of the present invention can be used as a cancer marker or as a reagent for preparing a monoclonal antibody with a specificity to the galactosyltransferase, which monoclonal antibody can be used as a diagnostic of a cancer. The monoclonal antibody of the invention specifically reacts with the cancer-related galactosyltransferase of the invention.