The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 22, 1994
Filed:
May. 16, 1989
Applicant:
Inventors:
Ewa Rakowicz-Szulczynska, Philadelphia, PA (US);
Hilary Koprowski, Wynnewood, PA (US);
Assignee:
The Wistar Institute of Anatomy and Biology, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; G01N / ; C07H / ; C12N / ;
U.S. Cl.
CPC ...
435-6 ; 435 71 ; 436501 ; 436503 ; 436508 ; 436514 ; 436531 ; 436548 ; 536 231 ; 536 235 ; 935 33 ; 935 34 ; 935 43 ;
Abstract
The present invention provides a method for selecting from among many monoclonal antibodies capable of binding to a surface antigen on a tumor cell, the antibody which also can internalize into the cell and exert an appropriate molecular effect on the level of gene regulation in the tumor cell. Such antibodies can most effectively be employed to damage the tumor cell.