2-piperazinone compounds and their use

Abstract

The compounds of the formula ##STR1## wherein G stands for an amidino group or an optionally cyclic amino group, these being respectively optionally substituted; D stands for a spacer having 2 to 6 atomic chain optionally bonded through a hetero-atom and/or a 5- to 6-membered ring (provided that the 5- to 6-membered ring is, depending on its bonding position, counted as 2 to 3 atomic chains); R.sup.1 stands for hydrogen, benzyl group or a lower alkyl group; R.sup.2 and R.sup.3 independently stand for a residual group formed by removing --CH(NH.sub.2)COOH from an .alpha.-amino acid, or R.sup.1 and R.sup.2 may form a 5- to 6-membered ring taken together with the adjacent N and C; X stands for hydrogen or an optionally substituted lower alkyl group; and Z stands for a group capable of forming an anion or a group convertible into an anion in a living body, or salts thereof and agents for inhibiting cell-adhesion, which are characterized by containing these compounds. The novel compounds and pharmaceutical agents are effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell adhesion.