The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 1994
Filed:
Jul. 20, 1993
Applicant:
Inventors:
Assignee:
L'Oreal, Paris, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ; C07D / ;
U.S. Cl.
CPC ...
554127 ; 554126 ; 554141 ; 554145 ; 554146 ; 554148 ; 549214 ; 549273 ; 556427 ; 556444 ; 568 23 ; 568852 ; 568857 ;
Abstract
The invention relates to a process for the manufacture of 6-trans-leukotriene B.sub.4 (LTB.sub.4) of formula ##STR1## in which a butadienediol is prepared; the hydroxyl groups are esterified to produce a diester and this diester is subjected to a stereospecific reductive elimination using low valency titanium [Ti(0)] to produce a 6-trans triether of formula: ##STR2## the groups --OA in positions 5 and 12 of which are then converted to --OH groups and the group --CH.sub.2 OA in position of which is then converted to a --COOH group, to produce 6-trans-LTB.sub.4. The invention also relates to intermediates obtained in the said manufacturing process.