The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 08, 1994
Filed:
Aug. 31, 1992
Pieter de Haan, Oss, NL;
Cornelus J Maria van der Ven, Uden, NL;
Akzo N.V., Belperweg, NL;
Abstract
Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble (>2 mg/ml) alkaline stabilizer. The resulting dry compositions are relatively more bioavailable and stable than compositions not containing the water soluble alkaline stabilizer, especially after high temperature (>45.degree.) granulation processes. The process for preparing the dry composition is also more 'rugged' with the added water soluble alkaline stabilizer.