The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 01, 1994

Filed:

Mar. 17, 1992
Applicant:
Inventors:

Takahiro Suzuki, Nagoya, JP;

Sukezo Kawamura, Inuyama, JP;

Motohiro Toriyama, Kasugai, JP;

Yoshiyuki Yokogawa, Nagoya, JP;

Yukari Kawamoto, Nagoya, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; A61K / ;
U.S. Cl.
CPC ...
435176 ; 424 9463 ;
Abstract

A fibrinolytic enzyme such as urokinase, tissue plasminogen activator or streptokinase is covalently bounded to a bioadaptable porous crystalline glass to produce a thrombolytic material. Production of the glass involves combining 40-50 mol% calcium oxide, 20-30 mol% titanium dioxide and 25-35 mol% diphosphorous pentoxide to form a mixture, and combining the mixture with 0.5-4.0 mol% disodium oxide. A bioreactor for converting plasminogen in blood into plasmin can be prepared by packing the material in a column. When finely comminuted, the material can be administered into the blood of a patient for removing blood clots.


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