The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 1994
Filed:
May. 04, 1992
Gyorgy Somogyi, Budapest, HU;
Peter Botka, Budapest, HU;
Gyula Horvath, Budapest, HU;
Antal Simay, Budapest, HU;
Roozsa Gyenge, Budapest, HU;
Imre Moravcsik, Budapest, HU;
Erno Orban, Budapest, HU;
Tamas Hamori, Budapest, HU;
Jeno Korosi, Budapest, HU;
Csilla Kiss, Budapest, HU;
Tibor Balogh, Budapest, HU;
Maria Bidlo nee Igloi, Budapest, HU;
nee Dievald Uskert, Budapest, HU;
Egis Gyogyszergyar Rt., Budapest, HU;
Abstract
The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of 1 mole of 2-acetonyl-3'-chloro-4,5-dimethoxybenzophenone of formula (II) ##STR2## with 3-7 moles of hydrazine hydrate in an organic solvent or in a mixture of organic solvents at a temperature between 15.degree. C. and 85.degree. C. is carried out in the absence of air oxygen, optionally in the presence of water. The crude product is then recrystallized from an aliphatic alcohol containing 1 to 5 carbon atom(s).