The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 1994
Filed:
Oct. 22, 1991
Applicant:
Inventors:
Gary R Strichartz, Boston, MA (US);
Sanjay Datta, Newton Centre, MA (US);
Markus Schneider, Basel, CH;
Assignee:
Brigham and Women's Hospital, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
514279 ; 514652 ; 514653 ; 514818 ; 424 10 ;
Abstract
A method of using veratridine to inhibit nerve impulses, and a composition of matter including veratridine and epinephrine, is provided. Application of veratridine proximal to a nerve causes depolarization of the nerve membrane, thereby blocking transmission of nerve impules. C-fiber selectivity is demonstrated in vitro in rabbit vagus nerves. Veratridine displays extended anesthetic activity over long periods of time when compared to similar local anesthetics, with no local toxicity. Systemic toxicity is reduced by co-injection with epinephrine.