The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 1994
Filed:
May. 13, 1993
Applicant:
Inventors:
William W Chin, Wellesley, MA (US);
Richard A Hodin, Brookline, MA (US);
Mitchell A Lazar, Havertown, PA (US);
Assignee:
Brigham and Women's Hospital, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
4352523 ; 435 641 ; 4353291 ; 536 235 ;
Abstract
The invention relates to the purification and cloning of a receptor for thyroid hormone. The receptor is designated PSTHR and is related to hormone receptors encoded by the genes erbA.alpha.-1, erbaA.alpha.-2 and erbA.beta.-1. The gene encoding PSTHR, erbA.beta.-2, is partially homologous to the erbA.beta.-1. However, PSTHR differs from the product of erbA.beta.-1 in that its expression is limited to the anterior pituitary gland. The invention additionally concerns the uses for PSTHR in the diagnosis and therapy of human conditions.