The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 18, 1994
Filed:
Sep. 03, 1991
Applicant:
Inventors:
H Edward Conrad, Alameda, CA (US);
Yuchuan Guo, Alameda, CA (US);
Assignee:
Glycomed Incorporated, Alameda, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C08B / ;
U.S. Cl.
CPC ...
514 56 ; 514 54 ; 536 21 ; 536 553 ; 536 551 ; 536 53 ; 536 54 ; 536 55 ;
Abstract
A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by antiproliferative activity with respect to smooth muscle cells. This NAC form of heparin is prepared by oxidizing heparin/heparan sulfate to a desired level with periodate followed by reduction of the resulting aldehyde groups; all under conditions which prevent depolymerization of the heparin.