The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 11, 1994

Filed:

Nov. 05, 1992
Applicant:
Inventors:

Quirico Branca, Basle, CH;

Marie-Paule Heitz, St. Louis, FR;

Marcel Muller, Frenkendorf, CH;

Werner Neidhart, Freiburg im Breisgau, DE;

Stadler Heinz, Rheinfelden, CH;

Eric Vieira, Basle, CH;

Wolfgang Wostl, Grenzach-Wyhlen, DE;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
514249 ; 514248 ; 514300 ; 514303 ; 544236 ; 544350 ; 544405 ; 546119 ; 546121 ; 546336 ; 548215 ; 564374 ; 564453 ;
Abstract

Compounds of the formula ##STR1## wherein A, B, X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as set forth in the specification, in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diasteromeric racemates as well as pharmaceutically acceptable salts thereof which inhibit the activity of the natural enzyme renin and are useful in the control or prevention of high blood pressure and cardiac insufficiency are described.


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