The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 1993
Filed:
Jul. 29, 1992
Applicant:
Inventor:
Moses N Lee, Greenville, SC (US);
Assignee:
Research Corporation Technologies, Inc., Tucson, AZ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514397 ; 514398 ; 514400 ; 5483157 ; 5483281 ; 5483285 ; 5483111 ; 5483151 ;
Abstract
The present invention relates to oligopeptide derivatives that are conjugated to DNA alkylating agents, having the formula ##STR1## wherein m is 0 to 4; n is 2 to 4; each R.sub.1 is the same or different and is hydrogen or C.sub.1 -C.sub.4 alkyl; and R is a DNA alkylating moiety. The present invention is further directed to pharmaceutical compositions thereof, and method for treatment of cancer using the subject compounds.