The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 1993
Filed:
Feb. 08, 1993
Applicant:
Inventors:
Takeshi Doi, Tsukuba, JP;
Akio Iwasaki, Matsudo, JP;
Yushi Saino, Tokyo, JP;
Shigeru Kimura, Higashiyamato, JP;
Masao Ohkuchi, Tokorozawa, JP;
Assignee:
Kowa Co., Ltd., Nagoya, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; A61K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
514-8 ; 530380 ; 530381 ; 514-2 ; 435 691 ; 435 693 ;
Abstract
Recombinant thrombin-binding substances, derived from thrombomodulin by modification of the c-terminal glycosaminoglycan (GAG) binding site and capable of promoting anti-thrombin III activity and inhibiting platelet aggregation, and by themselves possessing anti-thrombin activity are disclosed. The thrombin-binding substances are useful as an effective component of anticoagulant agents, and can be produced inexpensively in a large scale.